Pharmaceutical CAS 147-24-0 Diphenhydramine HCl Powder Diphenhydramine Hydrochloride

Diphenhydramine Hydrochloride is a first-generation antihistamine commonly used for its anti-allergic, antiemetic, and sedative properties. By blocking histamine H1 receptors, it effectively alleviates allergy symptoms such as hives, itching, and rhinitis, and is also indicated for motion sickness prevention and short-term sleep aid. The drug acts quickly but may cause drowsiness.

In clinical settings, Diphenhydramine finds use in managing extrapyramidal symptoms that may arise as side effects from certain antipsychotic medications. Its ability to mitigate drug-induced Parkinsonism and other dystonic reactions is well-documented. Topical formulations are available for direct application to the skin, offering localized relief from itching and discomfort due to minor burns, insect bites, or mild skin irritations.