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Diphenhydramine Hydrochloride is a first-generation Ethanolamin antihistamine with multiple pharmacological properties including central nervous system depression, anticholinergic effects, and local anesthetic action. It works by competitively antagonizing histamine H1 receptors, effectively reducing symptoms caused by allergic reactions such as vasodilation, increased capillary permeability, and smooth muscle spasm. This provides relief for conditions like allergic rhinitis, urticaria, pruritus, and angioedema.
| Parameter | Details |
| Product Name | Diphenhydramine Hydrochloride |
| Appearance | White crystalline powder |
| CAS No. | 147-24-0 |
| Molecular Formula | C17H22ClNO |
| Molecular Weight | 291.81568 |
Diphenhydramine Hydrochloride primarily exerts its therapeutic effects by competitively and reversibly antagonizing histamine at the H1 receptor. Beyond its use for allergies, it is commonly employed as a short-term sleep aid for insomnia and for the prevention and treatment of motion sickness and drug-induced nausea. It is also found in many over-the-counter cold and cough formulations.
